Adherens Junctions: from Molecular Mechanisms to Tissue by Tony Harris

By Tony Harris

Cell–cell adhesion is key for the improvement and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the easiest understood cell-cell adhesion complexes. during this quantity, a gaggle of the world over famous specialists experiences AJ biology over a variety of association; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and total animal improvement. AJs have additionally been a vital part of animal evolution, and play imperative roles in melanoma improvement, pathogen an infection and different ailments. This booklet addresses significant questions encompassing AJ biology.
• How did AJs evolve?
• How do cadherins and catenins engage to collect AJs and mediate adhesion?
• How do AJs interface with different mobile equipment to couple adhesion with the entire mobilephone?
• How do AJs impact mobilephone behaviour and multicellular improvement?
• How can irregular AJ job bring about disease?

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